实验服务
价格： 在线询价
地 址：北京
周 期：20天
*联系我时请说明是在易科学看到的，谢谢！
服务简介
新药研发过程中，药物的致心律失常毒性越来越受到关注。FDA即将推出的新指导原则全面致心律失常的心脏安全性评价（CiPA）又会给心脏安全性评价带来怎样的变革。爱思普普已准备好CiPA相关的所有离子通道。
Channel | KV11.1,hERG,IKr |
Catalog Ref. | ICE-HEK-hERG |
Gene | KCNH2 |
Sources | human |
Expression system | HEK293 |
Method | whole cell patch clamp |
Reference Inhibitor | E4031, cisapride |
Target | QT-prolongation, Torsade de Pointe(TdP) |
2. Nav1.5离子通道
Channel | NaV1.5 |
Gene | SCN5A |
Catalog Ref. | ICE-HEK-Nav1.5 |
Sources | human |
Expression system | HEK293 |
Method | whole cell patch clamp |
Reference inhibitor | TTX (1.0μM± 438.7nM) |
Target | Brugada syndrome, long QT syndrome, progressive cardiac conduction disease ,dilated cardiomyopathy, sick sinus syndrome, and atrial fibrillation |
3. Cav1.2 离子通道
Channel | Cav1.2/β2/α2/δ1, L-type |
Catalog Ref. | ICE-CHO-Cav1.2 |
Gene | CACNA1C |
Sources | human |
Expression system | CHO |
Method | whole cell patch clamp |
Reference Inhibitor | Nifedipine(31.3nM±6.8nM), verapamil |
Target | Timothy syndrome, long QT syndrome, Pain, epilepsy, hypertension, stroke, arrhythmia, Autism |
4. Iks离子通道
Channel | KvLQT/minK, IKs |
Gene | KCNQ1/KCNE1 |
Sources | Human |
Catalog Reference | ICE-HEK-IKs |
Expression system | HEK293 |
Method | whole cell patch clamp |
Standard time | 2 weeks |
Reference compound | Chromanol 293B (1.5µM±0.171µM) |
Target | Atrial fibrillation |
服务详情
